21-22-4 Mesotrione Pre-emergent Crabgrass Control and Fertilizer21 22 4 . 08 Mesotrione Pre emergent Crabgrass Control Mesotrione is a preemergent annual weed control that prevents the emergence of crabgrass seedlings and controls broadleaf weeds without harming desirable turf grasses. Turfgrass and lawns may be seeded and weeds controlled at the same time in comparison to other pre emergent weed controls like prodiamine. Apply mesotrione with fertilizer as the last step in the planting process. The 21% nitrogen,